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Potent inhibition of HIV replication in primary human cells by novel synthetic polyketides inspired by Aureothin
Overcoming the global health threat of HIV infection requires continuous pipelines of novel drug candidates. We identified the γ-pyrone polyketides Aureothin/Neoaureothin as potent hits by anti-HIV screening of an extensive natural compound collection. Total synthesis of a structurally diverse group...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987146/ https://www.ncbi.nlm.nih.gov/pubmed/31992748 http://dx.doi.org/10.1038/s41598-020-57843-9 |