cGMP favors the interaction between APP and BACE1 by inhibiting Rab5 GTPase activity

We previously demonstrated that cyclic guanosine monophosphate (cGMP) stimulates amyloid precursor protein (APP) and beta-secretase (BACE1) approximation in neuronal endo-lysosomal compartments, thus boosting the production of amyloid-β (Aβ) peptides and enhancing synaptic plasticity and memory. Her...

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Detalles Bibliográficos
Autores principales: Caudano, Francesca, Montalto, Giulia, Passalacqua, Mario, Pronzato, Maria A., Fedele, Ernesto, Ricciarelli, Roberta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987147/
https://www.ncbi.nlm.nih.gov/pubmed/31992816
http://dx.doi.org/10.1038/s41598-020-58476-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987147/
https://www.ncbi.nlm.nih.gov/pubmed/31992816
http://dx.doi.org/10.1038/s41598-020-58476-8

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