Shorter axon initial segments do not cause repetitive firing impairments in the adult presymptomatic G127X SOD-1 Amyotrophic Lateral Sclerosis mouse

Increases in axonal sodium currents in peripheral nerves are some of the earliest excitability changes observed in Amyotrophic Lateral Sclerosis (ALS) patients. Nothing is known, however, about axonal sodium channels more proximally, particularly at the action potential initiating region - the axon...

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Detalles Bibliográficos
Autores principales: Bonnevie, V. S., Dimintiyanova, K. P., Hedegaard, A., Lehnhoff, J., Grøndahl, L., Moldovan, M., Meehan, C. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987224/
https://www.ncbi.nlm.nih.gov/pubmed/31992746
http://dx.doi.org/10.1038/s41598-019-57314-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987224/
https://www.ncbi.nlm.nih.gov/pubmed/31992746
http://dx.doi.org/10.1038/s41598-019-57314-w

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