Prematurely aging mitochondrial DNA mutator mice display subchondral osteopenia and chondrocyte hypertrophy without further osteoarthritis features

Mitochondrial mutations and dysfunction have been demonstrated in several age-related disorders including osteoarthritis, yet its relative contribution to pathogenesis remains unknown. Here we evaluated whether premature aging caused by accumulation of mitochondrial DNA mutations in Polg(D275A) mice...

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Detalles Bibliográficos
Autores principales: Geurts, Jeroen, Nasi, Sonia, Distel, Pascal, Müller-Gerbl, Magdalena, Prolla, Tomas A., Kujoth, Gregory C., Walker, Ulrich A., Hügle, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987232/
https://www.ncbi.nlm.nih.gov/pubmed/31992827
http://dx.doi.org/10.1038/s41598-020-58385-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987232/
https://www.ncbi.nlm.nih.gov/pubmed/31992827
http://dx.doi.org/10.1038/s41598-020-58385-w

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