EGFR-vIII downregulated H2AZK4/7AC though the PI3K/AKT-HDAC2 axis to regulate cell cycle progression

BACKGROUND: The EGFR-vIII mutation is the most common malignant event in GBM. Epigenetic reprogramming in EGFR-activated GBM has recently been suggested to downregulate the expression of tumour suppressor genes. Histone acetylation is important for chromatin structure and function. However, the role...

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Detalles Bibliográficos
Autores principales: Zhao, Hongyu, Wang, Yunfei, Yang, Chao, Zhou, Junhu, Wang, Lin, Yi, Kaikai, Li, Yansheng, wang, Qixue, Shi, Jin, Kang, Chunsheng, Zeng, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987283/
https://www.ncbi.nlm.nih.gov/pubmed/31993801
http://dx.doi.org/10.1186/s40169-020-0260-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987283/
https://www.ncbi.nlm.nih.gov/pubmed/31993801
http://dx.doi.org/10.1186/s40169-020-0260-7

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