Spliced XBP1 Levels Determine Sensitivity of Multiple Myeloma Cells to Proteasome Inhibitor Bortezomib Independent of the Unfolded Protein Response Mediator GRP78

Background: Mechanisms mediating resistance against the proteasome inhibition by bortezomib (BTZ) in multiple myeloma (MM) cells are still unclear. We analyzed the activation of the unfolded protein response (UPR), induction of prosurvival, and apoptotic pathways after proteasome inhibition in BTZ-s...

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Detalles Bibliográficos
Autores principales: Borjan, Bojana, Kern, Johann, Steiner, Normann, Gunsilius, Eberhard, Wolf, Dominik, Untergasser, Gerold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987373/
https://www.ncbi.nlm.nih.gov/pubmed/32039016
http://dx.doi.org/10.3389/fonc.2019.01530

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987373/
https://www.ncbi.nlm.nih.gov/pubmed/32039016
http://dx.doi.org/10.3389/fonc.2019.01530

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