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Spliced XBP1 Levels Determine Sensitivity of Multiple Myeloma Cells to Proteasome Inhibitor Bortezomib Independent of the Unfolded Protein Response Mediator GRP78
Background: Mechanisms mediating resistance against the proteasome inhibition by bortezomib (BTZ) in multiple myeloma (MM) cells are still unclear. We analyzed the activation of the unfolded protein response (UPR), induction of prosurvival, and apoptotic pathways after proteasome inhibition in BTZ-s...
Autores principales: | Borjan, Bojana, Kern, Johann, Steiner, Normann, Gunsilius, Eberhard, Wolf, Dominik, Untergasser, Gerold |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987373/ https://www.ncbi.nlm.nih.gov/pubmed/32039016 http://dx.doi.org/10.3389/fonc.2019.01530 |
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