Osmotic diuresis by SGLT2 inhibition stimulates vasopressin‐induced water reabsorption to maintain body fluid volume

Most of the filtered glucose is reabsorbed in the early proximal tubule by the sodium‐glucose cotransporter SGLT2. The glycosuric effect of the SGLT2 inhibitor ipragliflozin is linked to a diuretic and natriuretic effect that activates compensatory increases in fluid and food intake to stabilize bod...

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Detalles Bibliográficos
Autores principales: Masuda, Takahiro, Muto, Shigeaki, Fukuda, Keiko, Watanabe, Minami, Ohara, Ken, Koepsell, Hermann, Vallon, Volker, Nagata, Daisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987478/
https://www.ncbi.nlm.nih.gov/pubmed/31994353
http://dx.doi.org/10.14814/phy2.14360

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987478/
https://www.ncbi.nlm.nih.gov/pubmed/31994353
http://dx.doi.org/10.14814/phy2.14360

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