Targeting dePARylation for cancer therapy

Poly(ADP-ribosyl)ation (PARylation) mediated by poly ADP-ribose polymerases (PARPs) plays a key role in DNA damage repair. Suppression of PARylation by PARP inhibitors impairs DNA damage repair and induces apoptosis of tumor cells with repair defects. Thus, PARP inhibitors have been approved by the...

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Detalles Bibliográficos
Autores principales: Kassab, Muzaffer Ahmad, Yu, Lily L., Yu, Xiaochun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988220/
https://www.ncbi.nlm.nih.gov/pubmed/32010441
http://dx.doi.org/10.1186/s13578-020-0375-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988220/
https://www.ncbi.nlm.nih.gov/pubmed/32010441
http://dx.doi.org/10.1186/s13578-020-0375-y

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