Cargando…

Targeting dePARylation for cancer therapy

Poly(ADP-ribosyl)ation (PARylation) mediated by poly ADP-ribose polymerases (PARPs) plays a key role in DNA damage repair. Suppression of PARylation by PARP inhibitors impairs DNA damage repair and induces apoptosis of tumor cells with repair defects. Thus, PARP inhibitors have been approved by the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kassab, Muzaffer Ahmad, Yu, Lily L., Yu, Xiaochun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988220/ https://www.ncbi.nlm.nih.gov/pubmed/32010441 http://dx.doi.org/10.1186/s13578-020-0375-y

Ejemplares similares

Targeting dePARylation selectively suppresses DNA repair–defective and PARP inhibitor–resistant malignancies
por: Chen, Shih-Hsun, et al.
Publicado: (2019)

DePARylation is critical for S phase progression and cell survival
por: Nie, Litong, et al.
Publicado: (2023)

Functions of PARylation in DNA Damage Repair Pathways
por: Wei, Huiting, et al.
Publicado: (2016)

Coupling bimolecular PARylation biosensors with genetic screens to identify PARylation targets
por: Krastev, Dragomir B., et al.
Publicado: (2018)

PARP Inhibitors as Therapeutics: Beyond Modulation of PARylation
por: Min, Ahrum, et al.
Publicado: (2020)

A Double-Edged Sword: The Two Faces of PARylation
por: Kang, Mincheol, et al.
Publicado: (2022)

PARylation During Transcription: Insights into the Fine-Tuning Mechanism and Regulation
por: Páhi, Zoltán G., et al.
Publicado: (2020)

NAMPT and PARylation Are Involved in the Pathogenesis of Atopic Dermatitis
por: Arroyo, Ana B., et al.
Publicado: (2023)

SPINDOC binds PARP1 to facilitate PARylation
por: Yang, Fen, et al.
Publicado: (2021)

The Enigmatic Function of PARP1: From PARylation Activity to PAR Readers
por: Kamaletdinova, Tatiana, et al.
Publicado: (2019)

New insight into the significance of KLF4 PARylation in genome stability, carcinogenesis, and therapy
por: Zhou, Zhuan, et al.
Publicado: (2020)

PARP2 mediates branched poly ADP-ribosylation in response to DNA damage
por: Chen, Qian, et al.
Publicado: (2018)

Histone Parylation factor 1 contributes to the inhibition of PARP1 by cancer drugs
por: Rudolph, Johannes, et al.
Publicado: (2021)

Chrysophanol protects against doxorubicin-induced cardiotoxicity by suppressing cellular PARylation
por: Lu, Jing, et al.
Publicado: (2019)

TET-mediated DNA hydroxymethylation is negatively influenced by the PARP-dependent PARylation
por: Tolić, Anja, et al.
Publicado: (2022)

NUPR1 protects against hyperPARylation-dependent cell death
por: Santofimia-Castaño, Patricia, et al.
Publicado: (2022)

Mammalian N1-adenosine PARylation is a reversible DNA modification
por: Musheev, Michael U., et al.
Publicado: (2022)

PARP1 mediated PARylation contributes to myogenic progression and glucocorticoid transcriptional response
por: Tan, Arnold, et al.
Publicado: (2023)

PARP1-mediated PARylation activity is essential for oligodendroglial differentiation and CNS myelination
por: Wang, Yan, et al.
Publicado: (2021)

Real-time monitoring of PARP1-dependent PARylation by ATR-FTIR spectroscopy
por: Krüger, Annika, et al.
Publicado: (2020)

5mC-hydroxylase activity is influenced by the PARylation of TET1 enzyme
por: Ciccarone, Fabio, et al.
Publicado: (2015)

SUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damage sites
por: González-Prieto, Román, et al.
Publicado: (2015)

Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome
por: Bacic, Luka, et al.
Publicado: (2021)

Increased PARylation impacts the DNA methylation process in type 2 diabetes mellitus
por: Zampieri, Michele, et al.
Publicado: (2021)

The dynamic process of covalent and non-covalent PARylation in the maintenance of genome integrity: a focus on PARP inhibitors
por: Beneyton, Adèle, et al.
Publicado: (2023)

DNA-PKcs PARylation regulates DNA-PK kinase activity in the DNA damage response
por: Han, Yang, et al.
Publicado: (2019)

PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation
por: Sun, Yilun, et al.
Publicado: (2021)

ZNF432 stimulates PARylation and inhibits DNA resection to balance PARPi sensitivity and resistance
por: O’Sullivan, Julia, et al.
Publicado: (2023)

Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation
por: Xu, Yan-Ran, et al.
Publicado: (2022)

Muscle PARP1 inhibition extends lifespan through AMPKα PARylation and activation in Drosophila
por: Guo, Shanshan, et al.
Publicado: (2023)

PC4-mediated Ku complex PARylation facilitates NHEJ-dependent DNA damage repair
por: Pan, Qimei, et al.
Publicado: (2023)

The role of poly ADP-ribosylation in the first wave of DNA damage response
por: Liu, Chao, et al.
Publicado: (2017)

PARP1 PARylates and stabilizes STAT5 in FLT3-ITD acute myeloid leukemia and other STAT5-activated cancers
por: Dellomo, Anna J., et al.
Publicado: (2021)

Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1α PARylation in db/db mice
por: Wang, Hong, et al.
Publicado: (2020)

Tankyrase inhibition preserves osteoarthritic cartilage by coordinating cartilage matrix anabolism via effects on SOX9 PARylation
por: Kim, Sukyeong, et al.
Publicado: (2019)

TSG101 associates with PARP1 and is essential for PARylation and DNA damage‐induced NF‐κB activation
por: Tufan, Ahmet Buğra, et al.
Publicado: (2022)

LGR5 regulates gastric adenocarcinoma cell proliferation and invasion via activating Wnt signaling pathway
por: Wang, Xiangfei, et al.
Publicado: (2018)

Correction: LGR5 regulates gastric adenocarcinoma cell proliferation and invasion via activating Wnt signaling pathway
por: Wang, Xiangfei, et al.
Publicado: (2019)

p53 Loss Mediates Hypersensitivity to ETS Transcription Factor Inhibition Based on PARylation-Mediated Cell Death Induction
por: Dinhof, Carina, et al.
Publicado: (2020)

PARP-mediated PARylation of MGMT is critical to promote repair of temozolomide-induced O(6)-methylguanine DNA damage in glioblastoma
por: Wu, Shaofang, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_cavlid4349qgsdno1sgvhdgttd