Cargando…

A deep learning image-based intrinsic molecular subtype classifier of breast tumors reveals tumor heterogeneity that may affect survival

BACKGROUND: Breast cancer intrinsic molecular subtype (IMS) as classified by the expression-based PAM50 assay is considered a strong prognostic feature, even when controlled for by standard clinicopathological features such as age, grade, and nodal status, yet the molecular testing required to eluci...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jaber, Mustafa I., Song, Bing, Taylor, Clive, Vaske, Charles J., Benz, Stephen C., Rabizadeh, Shahrooz, Soon-Shiong, Patrick, Szeto, Christopher W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988279/ https://www.ncbi.nlm.nih.gov/pubmed/31992350 http://dx.doi.org/10.1186/s13058-020-1248-3

Ejemplares similares

Deep Learning Implicitly Handles Tissue Specific Phenomena to Predict Tumor DNA Accessibility and Immune Activity
por: Wnuk, Kamil, et al.
Publicado: (2019)

Learning subgroup-specific regulatory interactions and regulator independence with PARADIGM
por: Sedgewick, Andrew J., et al.
Publicado: (2013)

Comprehensive genomic transcriptomic tumor-normal gene panel analysis for enhanced precision in patients with lung cancer
por: Rabizadeh, Shahrooz, et al.
Publicado: (2018)

Identification of an immune gene expression signature associated with favorable clinical features in Treg-enriched patient tumor samples
por: Givechian, Kevin B., et al.
Publicado: (2018)

An immunogenic NSCLC microenvironment is associated with favorable survival in lung adenocarcinoma
por: Givechian, Kevin B., et al.
Publicado: (2019)

Glycolytic expression in lower-grade glioma reveals an epigenetic association between IDH mutation status and PDL1/2 expression
por: Givechian, Kevin B, et al.
Publicado: (2020)

Single-cell sequencing and tumorigenesis: improved understanding of tumor evolution and metastasis
por: Ellsworth, Darrell L., et al.
Publicado: (2017)

Large scale, robust, and accurate whole transcriptome profiling from clinical formalin-fixed paraffin-embedded samples
por: Newton, Yulia, et al.
Publicado: (2020)

CAD/POLD2 gene expression is associated with poor overall survival and chemoresistance in bladder urothelial carcinoma
por: Givechian, Kevin B., et al.
Publicado: (2018)

Overcoming hypoxia-induced functional suppression of NK cells
por: Solocinski, Kristen, et al.
Publicado: (2020)

Protein and lipid MALDI profiles classify breast cancers according to the intrinsic subtype
por: Kang, Han Sung, et al.
Publicado: (2011)

Learning models for classifying Raman spectra of genomic DNA from tumor subtypes
por: Lancia, Giacomo, et al.
Publicado: (2023)

Molecular Subtyping of Serous Ovarian Tumors Reveals Multiple Connections to Intrinsic Breast Cancer Subtypes
por: Jönsson, Jenny-Maria, et al.
Publicado: (2014)

Immunotherapy utilizing the combination of natural killer– and antibody dependent cellular cytotoxicity (ADCC)–mediating agents with poly (ADP-ribose) polymerase (PARP) inhibition
por: Fenerty, Kathleen E., et al.
Publicado: (2018)

Correction to: Immunotherapy Utilizing the Combination of Natural Killer– and Antibody Dependent Cellular Cytotoxicity (ADCC)–Mediating Agents with Poly (ADP-ribose) polymerase (PARP) Inhibition
por: Fenerty, Kathleen E., et al.
Publicado: (2019)

The multi-functionality of N-809, a novel fusion protein encompassing anti-PD-L1 and the IL-15 superagonist fusion complex
por: Jochems, Caroline, et al.
Publicado: (2018)

A pathway activity-based proteomic classifier stratifies prostate tumors into two subtypes
por: Sun, Rui, et al.
Publicado: (2023)

Proteomic analysis of breast tumors confirms the mRNA intrinsic molecular subtypes using different classifiers: a large-scale analysis of fresh frozen tissue samples
por: Waldemarson, Sofia, et al.
Publicado: (2016)

Differential tumor infiltration by T-cells characterizes intrinsic molecular subtypes in breast cancer
por: Miyan, M., et al.
Publicado: (2016)

Tumor intrinsic immunity related proteins may be novel tumor suppressors in some types of cancer
por: Xiong, Donghai, et al.
Publicado: (2019)

MethPed: a DNA methylation classifier tool for the identification of pediatric brain tumor subtypes
por: Danielsson, Anna, et al.
Publicado: (2015)

Claudin gene expression profiles and clinical value in colorectal tumors classified according to their molecular subtype
por: Cherradi, Sara, et al.
Publicado: (2019)

Analysis of Tumor Microenvironment Heterogeneity among Breast Cancer Subtypes to Identify Subtype-Specific Signatures
por: Li, Ji, et al.
Publicado: (2022)

Transcriptomic analysis identifies a tumor subtype mRNA classifier for invasive non-functioning pituitary neuroendocrine tumor diagnostics
por: Bao, Xinjie, et al.
Publicado: (2021)

Integration of the Tumor Mutational Burden and Tumor Heterogeneity Identify an Immunological Subtype of Melanoma With Favorable Survival
por: Gao, Yanmei, et al.
Publicado: (2020)

Identification and validation of expressed HLA-binding breast cancer neoepitopes for potential use in individualized cancer therapy
por: Reimann, Hannah, et al.
Publicado: (2021)

Epigenetic mechanisms underlying subtype heterogeneity and tumor recurrence in prostate cancer
por: Chakraborty, Goutam, et al.
Publicado: (2023)

Combining functional genomics strategies identifies modular heterogeneity of breast cancer intrinsic subtypes
por: Pouladi, Nima, et al.
Publicado: (2014)

Exploitation of tumor antigens and construction of immune subtype classifier for mRNA vaccine development in bladder cancer
por: Zhang, Xin, et al.
Publicado: (2022)

Inferred Immune-Cell Activity Is an Independent Predictor of HER2-Negative Breast Cancer Prognosis and Response to Paclitaxel-Based Therapy in the GeparSepto Trial
por: Fasching, Peter A., et al.
Publicado: (2023)

PD-L1 targeting high-affinity NK (t-haNK) cells induce direct antitumor effects and target suppressive MDSC populations
por: Fabian, Kellsye P, et al.
Publicado: (2020)

Immune gene signatures and tumor intrinsic markers delineate novel immunogenic subtypes of breast cancer
por: Miller, Lance D, et al.
Publicado: (2014)

Morphology of Immunomodulation in Breast Cancer Tumor Draining Lymph Nodes Depends on Stage and Intrinsic Subtype
por: Seidl, Maximilian, et al.
Publicado: (2018)

Intrinsic Immunogenic Tumor Cell Death Subtypes Delineate Prognosis and Responsiveness to Immunotherapy in Lung Adenocarcinoma
por: He, Xiaotian, et al.
Publicado: (2023)

Breast Cancer Subtype Specific Classifiers of Response to Neoadjuvant Chemotherapy Do Not Outperform Classifiers Trained on All Subtypes
por: de Ronde, Jorma J., et al.
Publicado: (2014)

Why responses to immune checkpoint inhibitors are heterogeneous in head and neck cancers: Contributions from tumor-intrinsic and host-intrinsic factors
por: Chen, Zhangguo, et al.
Publicado: (2022)

An integrative deep learning framework for classifying molecular subtypes of breast cancer
por: Mohaiminul Islam, Md., et al.
Publicado: (2020)

Classifying Breast Cancer Molecular Subtypes by Using Deep Clustering Approach
por: Rohani, Narjes, et al.
Publicado: (2020)

Classifying tumors by supervised network propagation
por: Zhang, Wei, et al.
Publicado: (2018)

Classifying tumors by supervised network propagation
por: Zhang, Wei, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_6lak0263d64jgug278q02iupmm