Site- and degree-specific C–H oxidation on 5-methylcytosine homologues for probing active DNA demethylation

Ten-eleven translocation (TET) enzymes oxidize C–H bonds in 5-methylcytosine (5mC) to hydroxyl (5hmC), formyl (5fC) and carboxyl (5caC) intermediates en route to DNA demethylation. It has remained a challenge to study the function of a single oxidized product. We investigate whether alkyl groups oth...

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Detalles Bibliográficos
Autores principales: Kavoosi, Sam, Sudhamalla, Babu, Dey, Debasis, Shriver, Kirsten, Arora, Simran, Sappa, Sushma, Islam, Kabirul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988753/
https://www.ncbi.nlm.nih.gov/pubmed/32055378
http://dx.doi.org/10.1039/c9sc02629k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988753/
https://www.ncbi.nlm.nih.gov/pubmed/32055378
http://dx.doi.org/10.1039/c9sc02629k

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