Stereoselective Four-Component Synthesis of Functionalized 2,3-Dihydro-4-Nitropyrroles

We report a metal-free and stereoselective four-component reaction between α-ketoamides, amines, aromatic aldehydes and β-nitroalkenes or β-pivaloxy-nitroalkanes to obtain 2,3-dihydro-4-nitropyrroles functionalized in every position. The heterocycles accessible using this reaction may have utility i...

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Detalles Bibliográficos
Autores principales: Wang, Dong, Ma, Xinyue, Dong, Linru, Feng, Hairong, Yu, Peng, Désaubry, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988783/
https://www.ncbi.nlm.nih.gov/pubmed/32039135
http://dx.doi.org/10.3389/fchem.2019.00810
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author Wang, Dong
Ma, Xinyue
Dong, Linru
Feng, Hairong
Yu, Peng
Désaubry, Laurent
author_facet Wang, Dong
Ma, Xinyue
Dong, Linru
Feng, Hairong
Yu, Peng
Désaubry, Laurent
author_sort Wang, Dong
collection PubMed
description We report a metal-free and stereoselective four-component reaction between α-ketoamides, amines, aromatic aldehydes and β-nitroalkenes or β-pivaloxy-nitroalkanes to obtain 2,3-dihydro-4-nitropyrroles functionalized in every position. The heterocycles accessible using this reaction may have utility in the synthesis of pharmacologically active compounds.
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spelling pubmed-69887832020-02-07 Stereoselective Four-Component Synthesis of Functionalized 2,3-Dihydro-4-Nitropyrroles Wang, Dong Ma, Xinyue Dong, Linru Feng, Hairong Yu, Peng Désaubry, Laurent Front Chem Chemistry We report a metal-free and stereoselective four-component reaction between α-ketoamides, amines, aromatic aldehydes and β-nitroalkenes or β-pivaloxy-nitroalkanes to obtain 2,3-dihydro-4-nitropyrroles functionalized in every position. The heterocycles accessible using this reaction may have utility in the synthesis of pharmacologically active compounds. Frontiers Media S.A. 2019-11-26 /pmc/articles/PMC6988783/ /pubmed/32039135 http://dx.doi.org/10.3389/fchem.2019.00810 Text en Copyright © 2019 Wang, Ma, Dong, Feng, Yu and Désaubry. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Wang, Dong
Ma, Xinyue
Dong, Linru
Feng, Hairong
Yu, Peng
Désaubry, Laurent
Stereoselective Four-Component Synthesis of Functionalized 2,3-Dihydro-4-Nitropyrroles
title Stereoselective Four-Component Synthesis of Functionalized 2,3-Dihydro-4-Nitropyrroles
title_full Stereoselective Four-Component Synthesis of Functionalized 2,3-Dihydro-4-Nitropyrroles
title_fullStr Stereoselective Four-Component Synthesis of Functionalized 2,3-Dihydro-4-Nitropyrroles
title_full_unstemmed Stereoselective Four-Component Synthesis of Functionalized 2,3-Dihydro-4-Nitropyrroles
title_short Stereoselective Four-Component Synthesis of Functionalized 2,3-Dihydro-4-Nitropyrroles
title_sort stereoselective four-component synthesis of functionalized 2,3-dihydro-4-nitropyrroles
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988783/
https://www.ncbi.nlm.nih.gov/pubmed/32039135
http://dx.doi.org/10.3389/fchem.2019.00810
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