Lipid droplets can promote drug accumulation and activation

Genetic screens in cultured human cells represent a powerful unbiased strategy to identify cellular pathways that determine drug efficacy, providing critical information for clinical development. We used insertional mutagenesis-based screens in haploid cells to identify genes required for the sensit...

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Detalles Bibliográficos
Autores principales: Dubey, Ramin, Stivala, Craig E, Nguyen, Huy Quoc, Goo, Young-Hwa, Paul, Antoni, Carette, Jan E, Trost, Barry M, Rohatgi, Rajat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989039/
https://www.ncbi.nlm.nih.gov/pubmed/31932720
http://dx.doi.org/10.1038/s41589-019-0447-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989039/
https://www.ncbi.nlm.nih.gov/pubmed/31932720
http://dx.doi.org/10.1038/s41589-019-0447-7

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