Phage Resistance in Multidrug-Resistant Klebsiella pneumoniae ST258 Evolves via Diverse Mutations That Culminate in Impaired Adsorption

The evolution of phage resistance poses an inevitable threat to the efficacy of phage therapy. The strategic selection of phage combinations that impose high genetic barriers to resistance and/or high compensatory fitness costs may mitigate this threat. However, for such a strategy to be effective,...

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Detalles Bibliográficos
Autores principales: Hesse, Shayla, Rajaure, Manoj, Wall, Erin, Johnson, Joy, Bliskovsky, Valery, Gottesman, Susan, Adhya, Sankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989104/
https://www.ncbi.nlm.nih.gov/pubmed/31992617
http://dx.doi.org/10.1128/mBio.02530-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989104/
https://www.ncbi.nlm.nih.gov/pubmed/31992617
http://dx.doi.org/10.1128/mBio.02530-19

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