Plasmodium falciparum Resistance to a Lead Benzoxaborole Due to Blocked Compound Activation and Altered Ubiquitination or Sumoylation

New antimalarial drugs are needed. The benzoxaborole AN13762 showed excellent activity against cultured Plasmodium falciparum, against fresh Ugandan P. falciparum isolates, and in murine malaria models. To gain mechanistic insights, we selected in vitro for P. falciparum isolates resistant to AN1376...

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Detalles Bibliográficos
Autores principales: Sindhe, Kirthana M. V., Wu, Wesley, Legac, Jenny, Zhang, Yong-Kang, Easom, Eric E., Cooper, Roland A., Plattner, Jacob J., Freund, Yvonne R., DeRisi, Joseph L., Rosenthal, Philip J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989105/
https://www.ncbi.nlm.nih.gov/pubmed/31992618
http://dx.doi.org/10.1128/mBio.02640-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989105/
https://www.ncbi.nlm.nih.gov/pubmed/31992618
http://dx.doi.org/10.1128/mBio.02640-19

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