Efficient and Highly Specific Gene Transfer Using Mutated Lentiviral Vectors Redirected with Bispecific Antibodies

Despite their exceptional potencies, the broad tropism of most commonly used lentivirus (LV) vectors limits their use for targeted gene delivery in vivo. We hypothesized that we could improve the specificity of LV targeting by coupling (i) reduction of their binding to off-target cells with (ii) red...

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Detalles Bibliográficos
Autores principales: Parker, Christina L., Jacobs, Timothy M., Huckaby, Justin T., Harit, Dimple, Lai, Samuel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989108/
https://www.ncbi.nlm.nih.gov/pubmed/31964730
http://dx.doi.org/10.1128/mBio.02990-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989108/
https://www.ncbi.nlm.nih.gov/pubmed/31964730
http://dx.doi.org/10.1128/mBio.02990-19

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