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Stable Neutralization of a Virulence Factor in Bacteria Using Temperate Phage in the Mammalian Gut

Elimination or alteration of select members of the gut microbiota is key to therapeutic efficacy. However, the complexity of these microbial inhabitants makes it challenging to precisely target bacteria. Here, we deliver exogenous genes to specific bacteria by genomic integration of temperate phage...

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Detalles Bibliográficos
Autores principales: Hsu, Bryan B., Way, Jeffrey C., Silver, Pamela A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989128/
https://www.ncbi.nlm.nih.gov/pubmed/31992629
http://dx.doi.org/10.1128/mSystems.00013-20