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Extracellular matrix anisotropy is determined by TFAP2C-dependent regulation of cell collisions

The isotropic or anisotropic organisation of biological extracellular matrices has important consequences for tissue function. We study emergent anisotropy using fibroblasts that generate varying degrees of matrix alignment from uniform starting conditions. This reveals that the early migratory path...

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Detalles Bibliográficos
Autores principales: Park, Danielle, Wershof, Esther, Boeing, Stefan, Labernadie, Anna, Jenkins, Robert P, George, Samantha, Trepat, Xavier, Bates, Paul A, Sahai, Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989216/
https://www.ncbi.nlm.nih.gov/pubmed/31659294
http://dx.doi.org/10.1038/s41563-019-0504-3