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Pharmacodynamic principles and the time course of delayed and cumulative drug effects

This tutorial reviews the principles of the concentration — effect relationship for the usual case when drug effects are delayed relative to changes in circulating concentrations. The key processes determining delay are distribution from the circulation to the receptor, binding to the receptor to pr...

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Detalles Bibliográficos
Autor principal: Holford, Nick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Clinical Pharmacology and Therapeutics 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989261/
https://www.ncbi.nlm.nih.gov/pubmed/32055549
http://dx.doi.org/10.12793/tcp.2018.26.2.56