Introduction to in silico model for proarrhythmic risk assessment under the CiPA initiative

In 2005, the International Council for Harmonization (ICH) established cardiotoxicity assessment guidelines to identify the risk of Torsade de Pointes (TdP). It is focused on the blockade of the human ether-à-go-go-related gene (hERG) channel known to cause QT/QTc prolongation and the QT/QTc prolong...

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Detalles Bibliográficos
Autores principales: Park, Jin-Sol, Jeon, Ji-Young, Yang, Ji-Ho, Kim, Min-Gul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Clinical Pharmacology and Therapeutics 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989268/
https://www.ncbi.nlm.nih.gov/pubmed/32055576
http://dx.doi.org/10.12793/tcp.2019.27.1.12

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989268/
https://www.ncbi.nlm.nih.gov/pubmed/32055576
http://dx.doi.org/10.12793/tcp.2019.27.1.12

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