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Introduction to in silico model for proarrhythmic risk assessment under the CiPA initiative
In 2005, the International Council for Harmonization (ICH) established cardiotoxicity assessment guidelines to identify the risk of Torsade de Pointes (TdP). It is focused on the blockade of the human ether-à-go-go-related gene (hERG) channel known to cause QT/QTc prolongation and the QT/QTc prolong...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Korean Society for Clinical Pharmacology and Therapeutics
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989268/ https://www.ncbi.nlm.nih.gov/pubmed/32055576 http://dx.doi.org/10.12793/tcp.2019.27.1.12 |