A drug library screen identifies Carbenoxolone as novel FOXO inhibitor that overcomes FOXO3-mediated chemoprotection in high-stage neuroblastoma

The transcription factor FOXO3 has been associated in different tumor entities with hallmarks of cancer, including metastasis, tumor angiogenesis, maintenance of tumor-initiating stem cells, and drug resistance. In neuroblastoma (NB), we recently demonstrated that nuclear FOXO3 promotes tumor angiog...

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Detalles Bibliográficos
Autores principales: Salcher, Stefan, Spoden, Gilles, Hagenbuchner, Judith, Führer, Sebastian, Kaserer, Teresa, Tollinger, Martin, Huber-Cantonati, Petra, Gruber, Thomas, Schuster, Daniela, Gust, Ronald, Zwierzina, Heinz, Müller, Thomas, Kiechl-Kohlendorfer, Ursula, Ausserlechner, Michael J., Obexer, Petra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989399/
https://www.ncbi.nlm.nih.gov/pubmed/31591479
http://dx.doi.org/10.1038/s41388-019-1044-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989399/
https://www.ncbi.nlm.nih.gov/pubmed/31591479
http://dx.doi.org/10.1038/s41388-019-1044-7

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