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Vaccination with CD47 deficient tumor cells elicits an antitumor immune response in mice

Cancer cells are poorly immunogenic and have a wide range of mutations, which makes them unsuitable for use in vaccination treatment. Here, we show that elimination of CD47, a ligand for the myeloid cell inhibitory receptor SIRPα, from tumor cells by genetic deletion or antibody blocking, significan...

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Detalles Bibliográficos
Autores principales: Li, Yang, Zhang, Mingyou, Wang, Xiaodan, Liu, Wentao, Wang, Hui, Yang, Yong-Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989506/
https://www.ncbi.nlm.nih.gov/pubmed/31996683
http://dx.doi.org/10.1038/s41467-019-14102-4