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Mutual population-shift driven antibody-peptide binding elucidated by molecular dynamics simulations
Antibody based bio-molecular drugs are an exciting, new avenue of drug development as an alternative to the more traditional small chemical compounds. However, the binding mechanism and the effect on the conformational ensembles of a therapeutic antibody to its peptide or protein antigen have not ye...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989527/ https://www.ncbi.nlm.nih.gov/pubmed/31996730 http://dx.doi.org/10.1038/s41598-020-58320-z |