Unbalance Between Sarcoplasmic Reticulum Ca(2 +) Uptake and Release: A First Step Toward Ca(2 +) Triggered Arrhythmias and Cardiac Damage

The present review focusses on the regulation and interplay of cardiac SR Ca(2+) handling proteins involved in SR Ca(2+) uptake and release, i.e., SERCa2/PLN and RyR2. Both RyR2 and SERCA2a/PLN are highly regulated by post-translational modifications and/or different partners’ proteins. These contro...

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Autores principales: Federico, Marilén, Valverde, Carlos A., Mattiazzi, Alicia, Palomeque, Julieta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989610/
https://www.ncbi.nlm.nih.gov/pubmed/32038301
http://dx.doi.org/10.3389/fphys.2019.01630
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author Federico, Marilén
Valverde, Carlos A.
Mattiazzi, Alicia
Palomeque, Julieta
author_facet Federico, Marilén
Valverde, Carlos A.
Mattiazzi, Alicia
Palomeque, Julieta
author_sort Federico, Marilén
collection PubMed
description The present review focusses on the regulation and interplay of cardiac SR Ca(2+) handling proteins involved in SR Ca(2+) uptake and release, i.e., SERCa2/PLN and RyR2. Both RyR2 and SERCA2a/PLN are highly regulated by post-translational modifications and/or different partners’ proteins. These control mechanisms guarantee a precise equilibrium between SR Ca(2+) reuptake and release. The review then discusses how disruption of this balance alters SR Ca(2+) handling and may constitute a first step toward cardiac damage and malignant arrhythmias. In the last part of the review, this concept is exemplified in different cardiac diseases, like prediabetic and diabetic cardiomyopathy, digitalis intoxication and ischemia-reperfusion injury.
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spelling pubmed-69896102020-02-07 Unbalance Between Sarcoplasmic Reticulum Ca(2 +) Uptake and Release: A First Step Toward Ca(2 +) Triggered Arrhythmias and Cardiac Damage Federico, Marilén Valverde, Carlos A. Mattiazzi, Alicia Palomeque, Julieta Front Physiol Physiology The present review focusses on the regulation and interplay of cardiac SR Ca(2+) handling proteins involved in SR Ca(2+) uptake and release, i.e., SERCa2/PLN and RyR2. Both RyR2 and SERCA2a/PLN are highly regulated by post-translational modifications and/or different partners’ proteins. These control mechanisms guarantee a precise equilibrium between SR Ca(2+) reuptake and release. The review then discusses how disruption of this balance alters SR Ca(2+) handling and may constitute a first step toward cardiac damage and malignant arrhythmias. In the last part of the review, this concept is exemplified in different cardiac diseases, like prediabetic and diabetic cardiomyopathy, digitalis intoxication and ischemia-reperfusion injury. Frontiers Media S.A. 2020-01-23 /pmc/articles/PMC6989610/ /pubmed/32038301 http://dx.doi.org/10.3389/fphys.2019.01630 Text en Copyright © 2020 Federico, Valverde, Mattiazzi and Palomeque. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Federico, Marilén
Valverde, Carlos A.
Mattiazzi, Alicia
Palomeque, Julieta
Unbalance Between Sarcoplasmic Reticulum Ca(2 +) Uptake and Release: A First Step Toward Ca(2 +) Triggered Arrhythmias and Cardiac Damage
title Unbalance Between Sarcoplasmic Reticulum Ca(2 +) Uptake and Release: A First Step Toward Ca(2 +) Triggered Arrhythmias and Cardiac Damage
title_full Unbalance Between Sarcoplasmic Reticulum Ca(2 +) Uptake and Release: A First Step Toward Ca(2 +) Triggered Arrhythmias and Cardiac Damage
title_fullStr Unbalance Between Sarcoplasmic Reticulum Ca(2 +) Uptake and Release: A First Step Toward Ca(2 +) Triggered Arrhythmias and Cardiac Damage
title_full_unstemmed Unbalance Between Sarcoplasmic Reticulum Ca(2 +) Uptake and Release: A First Step Toward Ca(2 +) Triggered Arrhythmias and Cardiac Damage
title_short Unbalance Between Sarcoplasmic Reticulum Ca(2 +) Uptake and Release: A First Step Toward Ca(2 +) Triggered Arrhythmias and Cardiac Damage
title_sort unbalance between sarcoplasmic reticulum ca(2 +) uptake and release: a first step toward ca(2 +) triggered arrhythmias and cardiac damage
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989610/
https://www.ncbi.nlm.nih.gov/pubmed/32038301
http://dx.doi.org/10.3389/fphys.2019.01630
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