Cathepsin S activation contributes to elevated CX3CL1 (fractalkine) levels in tears of a Sjögren’s syndrome murine model

Autoimmune dacryoadenitis and altered lacrimal gland (LG) secretion are features of Sjögren’s syndrome (SS). Activity of cathepsin S (CTSS), a cysteine protease, is significantly and specifically increased in SS patient tears. The soluble chemokine, CX3CL1 (fractalkine), is cleaved from membrane-bou...

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Detalles Bibliográficos
Autores principales: Fu, Runzhong, Guo, Hao, Janga, Srikanth, Choi, Minchang, Klinngam, Wannita, Edman, Maria C., Hamm-Alvarez, Sarah F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989636/
https://www.ncbi.nlm.nih.gov/pubmed/31996771
http://dx.doi.org/10.1038/s41598-020-58337-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989636/
https://www.ncbi.nlm.nih.gov/pubmed/31996771
http://dx.doi.org/10.1038/s41598-020-58337-4

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