mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis

mTORC2 phosphorylates AKT in a hydrophobic motif site that is a biomarker of insulin sensitivity. In brown adipocytes, mTORC2 regulates glucose and lipid metabolism, however the mechanism has been unclear because downstream AKT signaling appears unaffected by mTORC2 loss. Here, by applying immunoblo...

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Detalles Bibliográficos
Autores principales: Martinez Calejman, C., Trefely, S., Entwisle, S. W., Luciano, A., Jung, S. M., Hsiao, W., Torres, A., Hung, C. M., Li, H., Snyder, N. W., Villén, J., Wellen, K. E., Guertin, D. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989638/
https://www.ncbi.nlm.nih.gov/pubmed/31996678
http://dx.doi.org/10.1038/s41467-020-14430-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989638/
https://www.ncbi.nlm.nih.gov/pubmed/31996678
http://dx.doi.org/10.1038/s41467-020-14430-w

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