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Positive surface charge of GluN1 N-terminus mediates the direct interaction with EphB2 and NMDAR mobility

Localization of the N-methyl-D-aspartate type glutamate receptor (NMDAR) to dendritic spines is essential for excitatory synaptic transmission and plasticity. Rather than remaining trapped at synaptic sites, NMDA receptors undergo constant cycling into and out of the postsynaptic density. Receptor m...

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Detalles Bibliográficos
Autores principales: Washburn, Halley R., Xia, Nan L., Zhou, Wei, Mao, Yu-Ting, Dalva, Matthew B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989673/
https://www.ncbi.nlm.nih.gov/pubmed/31996679
http://dx.doi.org/10.1038/s41467-020-14345-6