Arginine π-stacking drives binding to fibrils of the Alzheimer protein Tau

Aggregation of the Tau protein into fibrils defines progression of neurodegenerative diseases, including Alzheimer’s Disease. The molecular basis for potentially toxic reactions of Tau aggregates is poorly understood. Here we show that π-stacking by Arginine side-chains drives protein binding to Tau...

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Detalles Bibliográficos
Autores principales: Ferrari, Luca, Stucchi, Riccardo, Konstantoulea, Katerina, van de Kamp, Gerarda, Kos, Renate, Geerts, Willie J. C., van Bezouwen, Laura S., Förster, Friedrich G., Altelaar, Maarten, Hoogenraad, Casper C., Rüdiger, Stefan G. D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989696/
https://www.ncbi.nlm.nih.gov/pubmed/31996674
http://dx.doi.org/10.1038/s41467-019-13745-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989696/
https://www.ncbi.nlm.nih.gov/pubmed/31996674
http://dx.doi.org/10.1038/s41467-019-13745-7

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