Tetramer-Based Enrichment of Preexisting Anti-AAV8 CD8(+) T Cells in Human Donors Allows the Detection of a T(EMRA) Subpopulation

Pre-existing immunity to AAV capsid may compromise the safety and efficiency of rAAV-mediated gene transfer in patients. Anti-capsid cytotoxic immune responses have proven to be a challenge to characterize because of the scarcity of circulating AAV-specific CD8(+) T lymphocytes which can seldom be d...

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Detalles Bibliográficos
Autores principales: Vandamme, Céline, Xicluna, Rebecca, Hesnard, Leslie, Devaux, Marie, Jaulin, Nicolas, Guilbaud, Mickaël, Le Duff, Johanne, Couzinié, Célia, Moullier, Philippe, Saulquin, Xavier, Adjali, Oumeya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990124/
https://www.ncbi.nlm.nih.gov/pubmed/32038634
http://dx.doi.org/10.3389/fimmu.2019.03110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990124/
https://www.ncbi.nlm.nih.gov/pubmed/32038634
http://dx.doi.org/10.3389/fimmu.2019.03110

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