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Heparanase Loosens E-Cadherin-Mediated Cell-Cell Contact via Activation of Src
Activity of heparanase, responsible for cleavage of heparan sulfate (HS), is strongly implicated in tumor metastasis. This is due primarily to remodeling of the extracellular matrix (ECM) that becomes more prone to invasion by metastatic tumor cells. In addition, heparanase promotes the development...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990126/ https://www.ncbi.nlm.nih.gov/pubmed/32038981 http://dx.doi.org/10.3389/fonc.2020.00002 |