Rapid Characterization of hERG Channel Kinetics I: Using an Automated High-Throughput System

Predicting how pharmaceuticals may affect heart rhythm is a crucial step in drug development and requires a deep understanding of a compound’s action on ion channels. In vitro hERG channel current recordings are an important step in evaluating the proarrhythmic potential of small molecules and are n...

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Detalles Bibliográficos
Autores principales: Lei, Chon Lok, Clerx, Michael, Gavaghan, David J., Polonchuk, Liudmila, Mirams, Gary R., Wang, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990155/
https://www.ncbi.nlm.nih.gov/pubmed/31447109
http://dx.doi.org/10.1016/j.bpj.2019.07.029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990155/
https://www.ncbi.nlm.nih.gov/pubmed/31447109
http://dx.doi.org/10.1016/j.bpj.2019.07.029

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