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Rapid Characterization of hERG Channel Kinetics I: Using an Automated High-Throughput System
Predicting how pharmaceuticals may affect heart rhythm is a crucial step in drug development and requires a deep understanding of a compound’s action on ion channels. In vitro hERG channel current recordings are an important step in evaluating the proarrhythmic potential of small molecules and are n...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Biophysical Society
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990155/ https://www.ncbi.nlm.nih.gov/pubmed/31447109 http://dx.doi.org/10.1016/j.bpj.2019.07.029 |