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Safety and immunogenicity of the oral, inactivated, enterotoxigenic Escherichia coli vaccine ETVAX in Bangladeshi children and infants: a double-blind, randomised, placebo-controlled phase 1/2 trial

BACKGROUND: Enterotoxigenic Escherichia coli causes diarrhoea, leading to substantial mortality and morbidity in children, but no specific vaccine exists. This trial tested an oral, inactivated, enterotoxigenic E coli vaccine (ETVAX), which has been previously shown to be safe and highly immuongenic...

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Detalles Bibliográficos
Autores principales: Qadri, Firdausi, Akhtar, Marjahan, Bhuiyan, Taufiqur R, Chowdhury, Mohiul I, Ahmed, Tasnuva, Rafique, Tanzeem A, Khan, Arifuzzaman, Rahman, Sadia I A, Khanam, Farhana, Lundgren, Anna, Wiklund, Gudrun, Kaim, Joanna, Löfstrand, Madeleine, Carlin, Nils, Bourgeois, A Louis, Maier, Nicole, Fix, Alan, Wierzba, Thomas, Walker, Richard I, Svennerholm, Ann-Mari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science ;, The Lancet Pub. Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990395/
https://www.ncbi.nlm.nih.gov/pubmed/31757774
http://dx.doi.org/10.1016/S1473-3099(19)30571-7