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ATM, ATR and DNA-PKcs kinases—the lessons from the mouse models: inhibition ≠ deletion

DNA damage, especially DNA double strand breaks (DSBs) and replication stress, activates a complex post-translational network termed DNA damage response (DDR). Our review focuses on three PI3-kinase related protein kinases—ATM, ATR and DNA-PKcs, which situate at the apex of the mammalian DDR. They a...

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Detalles Bibliográficos
Autores principales: Menolfi, Demis, Zha, Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990542/
https://www.ncbi.nlm.nih.gov/pubmed/32015826
http://dx.doi.org/10.1186/s13578-020-0376-x