Cargando…
ATM, ATR and DNA-PKcs kinases—the lessons from the mouse models: inhibition ≠ deletion
DNA damage, especially DNA double strand breaks (DSBs) and replication stress, activates a complex post-translational network termed DNA damage response (DDR). Our review focuses on three PI3-kinase related protein kinases—ATM, ATR and DNA-PKcs, which situate at the apex of the mammalian DDR. They a...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990542/ https://www.ncbi.nlm.nih.gov/pubmed/32015826 http://dx.doi.org/10.1186/s13578-020-0376-x |