Association of Longitudinal Changes in Cerebrospinal Fluid Total Tau and Phosphorylated Tau 181 and Brain Atrophy With Disease Progression in Patients With Alzheimer Disease

IMPORTANCE: The amyloid/tau/neurodegeneration (A/T/N) framework uses cerebrospinal fluid (CSF) levels of total tau (tTau) as a marker of neurodegeneration and CSF levels of phosphorylated tau 181 (pTau181) as a marker of tau tangles. However, it is unclear whether CSF levels of tTau and pTau181 have...

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Detalles Bibliográficos
Autores principales: Llibre-Guerra, Jorge J., Li, Yan, Schindler, Suzanne E., Gordon, Brian A., Fagan, Anne M., Morris, John C., Benzinger, Tammie L. S., Hassenstab, Jason, Wang, Guoqiao, Allegri, Ricardo, Berman, Sarah B., Chhatwal, Jasmeer, Farlow, Martin R., Holtzman, David M., Jucker, Mathias, Levin, Johannes, Noble, James M., Salloway, Stephen, Schofield, Peter, Karch, Celeste, Fox, Nick C., Xiong, Chengjie, Bateman, Randall J., McDade, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2019
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6991202/
https://www.ncbi.nlm.nih.gov/pubmed/31825500
http://dx.doi.org/10.1001/jamanetworkopen.2019.17126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6991202/
https://www.ncbi.nlm.nih.gov/pubmed/31825500
http://dx.doi.org/10.1001/jamanetworkopen.2019.17126

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