Allopurinol reduces oxidative stress and activates Nrf2/p62 to attenuate diabetic cardiomyopathy in rats

Allopurinol (ALP) attenuates oxidative stress and diabetic cardiomyopathy (DCM), but the mechanism is unclear. Activation of nuclear factor erythroid 2‐related factor 2 (Nrf2) following the disassociation with its repressor Keap1 under oxidative stress can maintain inner redox homeostasis and attenu...

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Detalles Bibliográficos
Autores principales: Luo, Jierong, Yan, Dan, Li, Sisi, Liu, Shiming, Zeng, Fei, Cheung, Chi Wai, Liu, Hong, Irwin, Michael G., Huang, Huansen, Xia, Zhengyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6991641/
https://www.ncbi.nlm.nih.gov/pubmed/31856386
http://dx.doi.org/10.1111/jcmm.14870

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6991641/
https://www.ncbi.nlm.nih.gov/pubmed/31856386
http://dx.doi.org/10.1111/jcmm.14870

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