Deubiquitinase inhibitor degrasyn suppresses metastasis by targeting USP5‐WT1‐E‐cadherin signalling pathway in pancreatic ductal adenocarcinoma

Wilm's tumour‐1 (WT1) is overexpressed in pancreatic ductal adenocarcinoma (PDAC) and enhances metastasis. Deubiquitination stabilizes target proteins, and inhibiting deubiquitination facilitates the degradation of target proteins. However, whether inhibiting deubiquitination of WT1 facilitates...

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Detalles Bibliográficos
Autores principales: Li, Jiajia, Li, Haiying, Zhu, Weijian, Zhou, Bin, Ying, Jianchao, Wu, Jiansheng, Zhang, Huxiang, Sun, Hongwei, Gao, Shenmeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6991651/
https://www.ncbi.nlm.nih.gov/pubmed/31845546
http://dx.doi.org/10.1111/jcmm.14813

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6991651/
https://www.ncbi.nlm.nih.gov/pubmed/31845546
http://dx.doi.org/10.1111/jcmm.14813

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