Inhibition of MELK produces potential anti‐tumour effects in bladder cancer by inducing G1/S cell cycle arrest via the ATM/CHK2/p53 pathway

We aimed to investigate the biological function of MELK and the therapeutic potential of OTSSP167 in human bladder cancer (BCa). First, we observed overexpression of MELK in BCa cell lines and tissues and found that it was associated with higher tumour stage and tumour grade, which was consistent wi...

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Detalles Bibliográficos
Autores principales: Chen, Song, Zhou, Qiang, Guo, Zicheng, Wang, Yejinpeng, Wang, Lu, Liu, Xuefeng, Lu, Mengxin, Ju, Lingao, Xiao, Yu, Wang, Xinghuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6991658/
https://www.ncbi.nlm.nih.gov/pubmed/31821699
http://dx.doi.org/10.1111/jcmm.14878

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6991658/
https://www.ncbi.nlm.nih.gov/pubmed/31821699
http://dx.doi.org/10.1111/jcmm.14878

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