Krüppel‐like factor 4 regulates stemness and mesenchymal properties of colorectal cancer stem cells through the TGF‐β1/Smad/snail pathway

Krüppel‐like factor 4 (KLF4) was closely associated with epithelial‐mesenchymal transition and stemness in colorectal cancer stem cells (CSCs)‐enriched spheroid cells. Nonetheless, the underlying molecular mechanism is unclear. This study showed that KLF4 overexpression was accompanied with stemness...

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Detalles Bibliográficos
Autores principales: Leng, Zhengwei, Li, Yong, Zhou, Guojun, Lv, Xiaojiang, Ai, Walden, Li, Jianshui, Hou, Lingmi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6991673/
https://www.ncbi.nlm.nih.gov/pubmed/31830379
http://dx.doi.org/10.1111/jcmm.14882

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6991673/
https://www.ncbi.nlm.nih.gov/pubmed/31830379
http://dx.doi.org/10.1111/jcmm.14882

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