Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection

Mutations in Cu/Zn superoxide dismutase 1 (SOD1) associated with familial amyotrophic lateral sclerosis cause the protein to aggregate via a prion-like process in which soluble molecules are recruited to aggregates by conformational templating. These misfolded SOD1 proteins can propagate aggregation...

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Detalles Bibliográficos
Autores principales: Crown, Anthony, McAlary, Luke, Fagerli, Eric, Brown, Hilda, Yerbury, Justin J., Galaleldeen, Ahmad, Cashman, Neil R., Borchelt, David R., Ayers, Jacob I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6991973/
https://www.ncbi.nlm.nih.gov/pubmed/31999698
http://dx.doi.org/10.1371/journal.pone.0227655

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6991973/
https://www.ncbi.nlm.nih.gov/pubmed/31999698
http://dx.doi.org/10.1371/journal.pone.0227655

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