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Tks5 SH3 domains exhibit differential effects on invadopodia development
The Src substrate Tks5 helps scaffold matrix-remodeling invadopodia in invasive cancer cells. Focus was directed here on how the five SH3 domains of Tks5 impact that activity. Mutations designed to inhibit protein-protein interactions were created in the individual SH3 domains of Tks5, and the const...
Autores principales: | Daly, Christina, Logan, Brewer, Breeyear, Joseph, Whitaker, Kelley, Ahmed, Maryam, Seals, Darren F. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6991978/ https://www.ncbi.nlm.nih.gov/pubmed/31999741 http://dx.doi.org/10.1371/journal.pone.0227855 |
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