Abnormal LAMP1 glycosylation may play a role in Niemann-Pick disease, type C pathology

A hallmark of Niemann-Pick disease, type C (NPC) is the progressive degeneration of Purkinje neurons in the cerebellum caused by the accumulation of free cholesterol and glycosphingolipids in the lysosome. Recent studies suggest that the state of glycosylation of lysosomal membrane proteins may play...

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Detalles Bibliográficos
Autores principales: Cawley, Niamh X., Sojka, Caitlin, Cougnoux, Antony, Lyons, Anna T., Nicoli, Elena‐Raluca, Wassif, Christopher A., Porter, Forbes D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992233/
https://www.ncbi.nlm.nih.gov/pubmed/31999726
http://dx.doi.org/10.1371/journal.pone.0227829

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992233/
https://www.ncbi.nlm.nih.gov/pubmed/31999726
http://dx.doi.org/10.1371/journal.pone.0227829

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