Cargando…
Systemic loss of Sarm1 protects Schwann cells from chemotoxicity by delaying axon degeneration
Protecting the nervous system from chronic effects of physical and chemical stress is a pressing clinical challenge. The obligate pro-degenerative protein Sarm1 is essential for Wallerian axon degeneration. Thus, blocking Sarm1 function is emerging as a promising neuroprotective strategy with therap...
Autores principales: | Tian, Weili, Czopka, Tim, López-Schier, Hernán |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992705/ https://www.ncbi.nlm.nih.gov/pubmed/32001778 http://dx.doi.org/10.1038/s42003-020-0776-9 |
Ejemplares similares
-
Blocking Wallerian degeneration by loss of Sarm1 does not promote axon resealing in zebrafish
por: Tian, Weili, et al.
Publicado: (2020) -
Sarm1 is dispensable for mechanosensory-motor transformations in zebrafish
por: Asgharsharghi, Amir, et al.
Publicado: (2021) -
Multifaceted roles of SARM1 in axon degeneration and signaling
por: Waller, Thomas J., et al.
Publicado: (2022) -
TIR-1/SARM1 inhibits axon regeneration and promotes axon degeneration
por: Czech, Victoria L, et al.
Publicado: (2023) -
Sarm1 haploinsufficiency or low expression levels after antisense oligonucleotides delay programmed axon degeneration
por: Gould, Stacey Anne, et al.
Publicado: (2021)