Rewiring of endogenous signaling pathways to genomic targets for therapeutic cell reprogramming

Rewiring cellular sensors to trigger non-natural responses is fundamental for therapeutic cell engineering. Current designs rely on engineered receptors that are limited to single inputs, and often suffer from high leakiness and low fold induction. Here, we present Generalized Engineered Activation...

Descripción completa

Detalles Bibliográficos
Autores principales: Krawczyk, Krzysztof, Scheller, Leo, Kim, Hyojin, Fussenegger, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992713/
https://www.ncbi.nlm.nih.gov/pubmed/32001704
http://dx.doi.org/10.1038/s41467-020-14397-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992713/
https://www.ncbi.nlm.nih.gov/pubmed/32001704
http://dx.doi.org/10.1038/s41467-020-14397-8

Ejemplares similares