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Rewiring of endogenous signaling pathways to genomic targets for therapeutic cell reprogramming
Rewiring cellular sensors to trigger non-natural responses is fundamental for therapeutic cell engineering. Current designs rely on engineered receptors that are limited to single inputs, and often suffer from high leakiness and low fold induction. Here, we present Generalized Engineered Activation...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992713/ https://www.ncbi.nlm.nih.gov/pubmed/32001704 http://dx.doi.org/10.1038/s41467-020-14397-8 |