Tumor heterogeneity and clonal cooperation influence the immune selection of IFN-γ-signaling mutant cancer cells

PD-1/PD-L1 blockade can promote robust tumor regression yet secondary resistance often occurs as immune selective pressure drives outgrowth of resistant tumor clones. Here using a genome-wide CRISPR screen in B16.SIY melanoma cells, we confirm Ifngr2 and Jak1 as important genes conferring sensitivit...

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Detalles Bibliográficos
Autores principales: Williams, Jason B., Li, Shuyin, Higgs, Emily F., Cabanov, Alexandra, Wang, Xiaozhong, Huang, Haochu, Gajewski, Thomas F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992737/
https://www.ncbi.nlm.nih.gov/pubmed/32001684
http://dx.doi.org/10.1038/s41467-020-14290-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992737/
https://www.ncbi.nlm.nih.gov/pubmed/32001684
http://dx.doi.org/10.1038/s41467-020-14290-4

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