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Two faces of bivalent domain regulate VEGFA responsiveness and angiogenesis
The bivalent domain (BD) at promoter region is an unique epigenetic feature poised for activation or repression during cell differentiation in embryonic stem cell. However, the function of BDs in already differentiated cells remains exclusive. By profiling the epigenetic landscape of endothelial cel...
Autores principales: | Chen, Jiahuan, Liang, Xiaodong, Zhang, Shasha, Wang, Shiyan, Garcia, Sara P., Yan, Pengyi, Yu, Huijing, Li, Zixuan, Liu, Li, Zhang, Fang, Wei, Weiting, Le, Huangying, Zhang, Yan, Yuan, Guo-cheng, Chen, Sun, Chen, Yingwei, Sun, Kun, Pu, William T., Zhang, Bing |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992747/ https://www.ncbi.nlm.nih.gov/pubmed/32001672 http://dx.doi.org/10.1038/s41419-020-2228-3 |
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